2002

1. Hirade K, Kozawa O, Tanabe K, Niwa M, Matsuno H, Oiso Y, Akamatsu S, Ito H, Kato K, Katagiri Y, Uematsu T.
Thrombin stimulates dissociation and induction of HSP27 via p38 MAPK in vascular smooth muscle cells.
Am. J. Physiol. Heart Circ. Physiol. 2002;283:H941-H948.

2. Yamamoto T, Kozawa O, Tanabe K, Akamatsu S, Matsuno H, Dohi S. Hirose H, Uematsu T.
1,25-Dihydroxyvitamin D3 stimulates vascular endothelial growth actor release in aortic smooth muscle cell: role of p38 mitogen-activated protein kinase.
Arch. Biochem. Biophys. 2002;398:1-6.

3. Hatakeyama D, Kozawa O, Niwa M, Matsuno H, Ito H, Kato K, Tatematsu N, Shibata T, Uematsu T.
Upregulation by retinoic acid of transforming growth factor- β-stimulated heat shock protein 27 induction in osteoblasts: involvement of mitogen-activated protein kinases.
Biochim. Biophys. Acta Mol. Cell Res. 2002;1589:15-30.

4. Matsuno H, Kozawa O, Yoshimi N, Akamatsu S, Hara A, Mori H, Okada K, Ueshima S, Matsuo O, Uematsu T.
Lack of α2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction.
Blood. 2002;100:2487-2493.

5. Kozawa O, Otsuka T, Uematsu T:
Leukemia inhibitory factor enhances bFGF-induced IL-6 synthesis in osteoblasts: involvement of JAK2/STAT3.
Cell. Signal. 2002;14:311-315.

6. Kozawa O, Hatakeyama D, Tokuda H, Oiso Y, Matsuno H, Uematsu T.
Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of cramide.
Cell. Signal. 2002;14:999-1004.

7. Hotta K, Niwa M, Hirota M, Kanamori Y, Matsuno H, Kozawa O, Otsuka T, Matsui N, Uematsu T.
Regulation of fluoroquinolone uptake by human neutrophils: involvement of mitogen-activated protein kinase.
J. Antimicrob. Chemother. 2002;49:953-959.

8. Niwa M, Kanamori Y, Hotta K, Matsuno H, Kozawa O, Fujimoto S, Uematsu T.
Priming by grepafloxacin on respiratory burst of human neutrophils: its possible mechanism.
J. Antimicrob. Chemother. 2002;50:469-478.

9. Matsuno H, Kozawa O, Okada K, Ueshima S, Matsuno O, Uematsu T.
Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice.
J. Cardiovasc. Pharmacol. 2002;39:278-286.

10. Tanabe K, Kozawa O, Niwa M, Yamamoto T, Matsuno H, Ito H, Kato K, Dohi S, Uematsu T.
Contrasting effects of midazolam on induction of heat shock protein 27 by vasopressin and heat in aortic smooth muscle cells.
J. Cell. Biochem. 2002;84:39-46.

11. Kozawa O, Hatakeyama D, Uematsu T.
Divergent regulation by p44/42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts.
J. Cell. Biochem. 2002;84:583-589.

12. Hatakeyama D, Kozawa O, Otsuka T, Shibata T, Uematsu T.
Zinc suppresses IL-6 synthesis by prostaglandin F2α in osteoblasts: inhibition of phospholipase C and phospholipase D.
J. Cell. Biochem. 2002;85:621-628.

13. Kozawa O, Niwa M, Hatakeyama D, Tokuda H, Oiso Y, Matsuno H, Kato K, and Uematsu T.
Specific Induction of Heat Shock Protein 27 by Glucocorticoid in Osteoblasts.
J. Cell. Biochem. 2002;86:357-364.

14. Wang X, Tokuda H, Hirade K, Kozawa O.
Stress-activated protein kinase/c-Jun N-terminal kinase (JNK) plays a part in endothelin-1-induced vascular endothelial growth factor synthesis in osteoblasts.
J. Cell. Biochem. 2002;87:417-423.

15. Matsuno H, Uematsu T, Niwa M, Kozawa O, Nagashima S, Kohno K, Kato H, Kawabata Y, Yoshida Y, Kanamaru M.
Pharmacokinetic and pharmacodynamic properties of a new thromboxane receptor antagonist (Z-335) after single and multiple oral administrations to healthy volunteers.
J. Clin. Pharmacol. 2002;42:782-790

16. Tokuda H, Kozawa O, Niwa M, Matsuno H, Kato K, Uematsu T.
Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells.
J. Endocrinol. 2002;172:271-281.

17. Kozawa O, Matsuno H, Niwa M, Hatakeyama D, Oiso Y, Kato K, Uematsu T.
HSP20, low-molecular-weight heat shock-related protein, acts extracellularly as a regulator of platelet functions: a novel defense mechanism.
Life Sci. 2002.72:113-124.

18. Wang X, Niwa M, Hara A, Matsuno H, Kawase K, Kozawa O, Mori H, Uematsu T.
Neuronal degradation in mouse retina after a transient ischemia and protective effect of hypothermia.
Neurol. Res. 2002;24:730-735.

19. Tokuda H, Kozawa O, Uematsu T.
Interleukin (IL)-17 enhances proataglandin F2α-stimulated IL-6 synthesis in osteoblasts.
Prostaglandins Leukot. Essent. Fatty Acids. 2002;66:427-433.

20. Matsuno H, Kozawa O, Okada K, Ueshima S, Matsuo O, Uematsu T.
Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.
Thromb. Haemost. 2002;87:98-104.

21. Takei M, Matsuno H, Okada K, Ueshima S, Matsuo O and Kozawa O.
Lack of α2-antiplasmin enhances ADP induced platelet micro-aggregation through the presence of excess active plasmin in mice.
J. Thromb. Thrombolys 2002;14:205-211.