Department of Pharmacology, Gifu University Graduate School of Medicine




研究業績リスト
Original Article
  [2017]
1. Takagi T, Imai T, Mishiro K, Ishisaka M, Tsujimoto M, Ito H, Nagashima K, Matsukawa H, Tsuruma K, Shimazawa M, Yoshimura S, Kozawa O, Iwama T, and Hara H. Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood-brain barrier.
J. Cereb. Blood Flow Metab. 2017;37:123-139.
2. Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Matsushima-Nishiwaki R, Kozawa O and Otsuka T. Attenuation by normoxic HIF inducers on prostaglandin E1-induced osteoprotegerin synthesis inosteoblasts.
Mol. Med. Rep. 2017;15:1847-1852.
3. Fujita K, Tokuda H, Kainuma S, Kuroyanagi G, Yamamoto N, Matsushima- Nishiwaki R, Harada A, Kozawa O and Otsuka T. Resveratrol suppresses thyroid hormone-induced osteocalcin synthesis in osteoblasts.
Mol. Med. Rep.
2017;16:2881-2886.

4. Fujita K, Otsuka T, Yamamoto N, Kainuma S, Ohguchi R, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Kozawa O and Tokuda H. (-)- Epigallocatechin gallate but not chlorogenic acid up-regulates osteoprotegerin synthesis by bone morphogenetic protein-4 in osteoblasts.
Exp. Ther. Med. 2017;14:417-423.
5. Fujita K, Tokuda H, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Harada A, Kozawa O and Otsuka T. Incretin amplifies TNF-α-stimulated IL-6 synthesis in osteoblasts: suppression of the IκB/NF-κB pathway.
Int. J. Mol. Med. 2017;39:1053-1060.
6. Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Harada A, Kozawa O and Otsuka T. (-)-Epigallocatechin gallate synergistically potentiates prostaglandin E2- stimulated osteoprotegerin synthesis in osteoblasts.
Prostag. Oth. Lipid M. 2017:128-129;27-33.
7. Kainuma S, Tokuda H, Yamamoto N, Kuroyanagi G, Fujita K, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O and Otsuka T. Heat shock protein 27 (HSPB1) suppresses PDGF-BB-induced migration of osteoblasts.
Int. J. Mol. Med. 2017;40:1057-1066.
8. Matsushima-Nishiwaki R, Toyoda H, Takamatsu R, Yasuda E, Okuda S, Maeda A, Kaneoka Y, Yoshimi N, Kumada T and Kozawa O. Heat shock protein 22 (HSPB8) reduces the migration of hepatocellular carcinoma cells through the suppression of the phosphoinositide 3-kinase (PI3K)/AKT pathway.
Biochim. Biophys Acta-Mol. Basis Dis. 2017:1863;1629-1639.
9. Fujita K, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O and Otsuka T. HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts.
PLoS One. 2017;12:e0177878.
10. Sakai G, Otsuka T, Fujita K, Kainuma S, Kuroyanagi G, Kawabata T, Matsushima- Nishiwaki R, Kozawa O and Tokuda H. Amplification by (-)-epigallocatechin gallate of prostaglandin F2α-stimulated synthesis of osteoprotegerin in osteoblasts.
Mol. Med. Rep. 2017;16:6376-6381.
11. Onuma T, Tanabe K, Kito Y, Tsujimoto M, Enomoto Y, Matsushima-Nishiwaki R, Doi T, Nagase K, Akamatsu S, Tokuda H, Ogura S, Iwama T, Kozawa O and Iida H. Sphingosine 1-phosphate (S1P) suppresses collagen-induced activation of human platelets via S1P4 receptor.
Thromb. Res. 2017;156:91-100.
12.  Kawabata T, Tokuda H, Fujita K, Kainuma S, Sakai G, Matsushima-Nishiwaki R, Kozawa O and Otsuka T. Resveratrol inhibits the epidermal growth factor-induced migration of osteoblasts: the suppression of SAPK/JNK and Akt.
Cell. Physiol. Biochem. 2017;43:1025-1036.
13.  Kawabata T, Otsuka T, Fujita K, Kainuma S, Yamamoto N, Kuroyanagi G, Sakai G, Matsushima-Nishiwaki R, Kozawa O and Tokuda H. Suppression by HSP90 inhibitors of BMP-4-stimulated osteoprotegerin synthesis in osteoblasts: attenuation of p70 S6 kinase.
Mol. Med. Rep. 2017;16:8507-8512.
14.  Sakai G, Tokuda H, Fujita K, Kainuma S, Kawabata T, Matsushima-Nishiwaki R, Kozawa O and Otsuka T. Heat shock protein 70 negatively regulates TGF-β- stimulated VEGF synthesis via p38 MAP kinase in osteoblasts.
Cell. Physiol. Biochem. 2017;44:1133-1145.



Department of Pharmacology, Gifu University Graduate School of Medicine