Department of Pharmacology, Gifu University Graduate School of Medicine




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@ [2011]
1. Natsume H, Tokuda H, Adachi S, Matsushima-Nishiwaki R, Kato K, Minamitani C, Otsuka T and Kozawa O. Wnt3a regulates tumor necrosis factor-a-stimulated interleukin-6 release in osteoblasts.
Mol.cell.Endocrinol. 2011;331:66-72.
2. Adachi S, Yasuda I, Nakashima M, Yamauchi T, Yoshioka T, Okano Y, Moriwaki H and Koza
wa O. Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells.
Eur. J. Pharmacol. 2011;650:145-150.

3. Kato K, Otsuka T, Adachi S, Matsushima-Nishiwaki R, Natsume H, Kozawa O and Tokuda H. (-)-Epigallocatechin gallate inhibits thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.
Mol. Med. Rep. 2011;4:297-300.

4. Kato K, Tokuda H, Adachi S, Matsushima-Nishiwaki R, Yamauchi J, Natsume H, Minamitani C, Mizutani J, Otsuka T and Kozawa O. Role of heat shock protein 27 in transforming growth factor--stimulated vascular endothelial growth factor release in osteoblasts.
Int. J. Mol. Med. 2011;27:423-428.
5. Tokuda H, Adachi S, Matsushima-Nishiwaki R, Kato K, Natsume H, Otsuka T and Kozawa O. Enhancement of basic fibroblast growth factor-stimulated VEGF synthesis by Wnt3a in osteoblasts.
Int. J. Mol. Med. 2011;27:859-864.
6. Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, Matsushima-Nishiwaki R, Akamatsu S, Tokuda H, Yoshimura S, Otsuka T, Ogura S, Kozawa O and Iwama T. cAMP regulates ADP-induced HSP27 phosphorylation in human platelets.
Int. J. Mol. Med. 2011;27:695-700.
7. Kato K, Adachi S, Matsushima-Nishiwaki R, Minamitani C, Natsume H, Katagiri Y, Hirose Y, Mizutani J, Tokuda H, Kozawa O and Otsuka T. Regulation by heat shock protein 27 of osteocalcin synthesis in osteoblasts.
Endocrinology. 2011;152:1872-1882.
8. Natsume H, Tokuda H, Matsushima-Nishiwaki R, Kato K, Yamakawa K, Otsuka T and Kozawa O. Wnt3a up-regulates transforming growth factor-b-stimulated VEGF synthesis in osteoblasts.
Cell Biochem. Funct. 2011;29:371-377.

9. Kato K, Otsuka T, Matsushima-Nishiwaki R, Natsume H, Kozawa O and Tokuda H. Rho-kinase regulates thrombin-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.
Int. J. Mol. Med. 2011;28:653-658.

10. Yamauchi T, Adachi S, Yasuda I, Nakashima M, Kawaguchi J, Nishii Y, Yoshioka T, Okano Y, Hirose Y, Kozawa O and Moriwaki H. UV-C irradiation induces downregulation of EGF receptors via phosphorylation at serine 1046/1047 in human pancreatic cancer cells.
Radiat. Res. 2011;176:565-574.
11. Tanabe K, Kozawa O and Iida H. Midazolam suppresses interleukin-1-induced interleukin-6 release from rat glial cells.
J. Neuroinflamm. 2011;8:68.

12.
Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Hanamatsu T, Yoshioka T, Okano Y, Hirose Y, Kozawa O and Moriwaki H. Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells.
Mol. Cancer. 2011;10:79.
13. Adachi S, Yasuda I, Nakashima M, Yamauchi T, Kawaguchi J, Shimizu M, Itani M, Nakamura M, Nishii Y, Yoshioka T, Hirose Y, Okano Y, Moriwaki H and Kozawa O. Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor.
J. Biol. Chem. 2011;286:26178-26187.
14. Yamauchi T, Adachi S, Yasuda I, Nakashima M, Kawaguchi J, Yoshioka T, Hirose Y, Kozawa O and Moriwaki H. Ultra-violet irradiation induces apoptosis via mitochondrial pathway in pancreatic cancer cells.
Int. J. Oncol. 2011;39:1375-1380.
15. Kato K, Tokuda H, Mizutani J, Adachi S, Matsushima-Nishiwaki R, Natsume H, Kozawa O and Otsuka T. Role of HSP27 in tumor necrosis factor-a-stimulated interleukin-6 synthesis in osteoblasts.
Int. J. Mol. Med. 2011;28:887-893.
16. Matsushima-Nishiwaki R, Adachi S, Yoshioka T, Yasuda E, Yamagishi Y, Matsuura J, Muko M, Iwamura R, Noda T, Toyoda H, Kaneoka Y, Okano Y, Kumada T and Kozawa O. Suppression by heat shock protein 20 of hepatocellular carcinoma cell proliferation via inhibition of the mitogen-activated protein kinases and Akt pathways.
J. Cell. Biochem.2011;112:3430-3439.
17. Adachi S, Yasuda I, Kawaguchi J, Yamauchi T, Nakashima M, Itani M, Nakamura M, Yoshioka T, Moriwaki H and Kozawa O. Ultraviolet enhances the sensitivity of pancreatic cancer cells to gemcitabine by activation of 5f AMP-activated protein kinase.
Biochem. Biophys. Res. Commun. 2011;414:53-59.
18. Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Itani M, Yoshioka T, Matsushima-Nishiwaki R, Hirose Y, Kozawa O and Moriwaki H. Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells.
Cancer Lett. 2011;313:218-225.



Department of Pharmacology, Gifu University Graduate School of Medicine