Department of Pharmacology, Gifu University Graduate School of Medicine




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@ [2010]
1. Tokuda H, Harada A, Adachi S, Matsushima-Nishiwaki R, Natsume H, Minamitani C, Mizutani J, Otsuka T and Kozawa O. Raloxifene enhances spontaneous microaggregation of platelets through up-regulation of p44/p42 MAP kinase: a case report.
Osteoporosis Int. 2010;21:189-193.
2. Tokuda H, Adachi S, Matsushima-Nishiwaki R, Hanai Y, Takai S, Harada A and Kozawa O. Inhibition by minodronate of basic fibroblast growth factor-stimulated vascular endothelial growth factor synthesis in osteoblast-like cells.
Mol. Med. Rep. 2010;3:167-171.

3. Takai S, Tokuda H, Matsushima-Nishiwaki R, Saio M, Takami T and Kozawa O. TGF- superfamily enhances the antigen-induced IFN- production by effector/memory CD8+ T cells.
Int. J. Mol. Med. 2010;25:105-111.

4. Minamitani C, Tokuda H, Adachi S, Matsushima-Nishiwaki R, Yamauchi J, Kato K, Natsume H, Mizutani J, Kozawa O and Otsuka T. p70 S6 kinase limits tumor necrosis factor--induced interleukin-6 synthesis in osteoblast-like cells.
Mol. Cell. Endocrinol. 2010;315:195-200.
5. Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Doi T, Niwa M, Akamatsu S, Tokuda H, Ogura S, Yoshimura S, Iwama T and Kozawa O. Thromboxane A2 promotes soluble CD40 ligand release from human platelets.
Atherosclerosis. 2010;209:415-421.

6. Kato H, Adachi S, Doi T, Matsushima-Nishiwaki R, Minamitani C, Akamatsu S, Enomoto Y, Tokuda H, Otsuka T, Iwama T, Kozawa O and Ogura S. Mechanism of collagen-induced release of 5-HT, PDGF-AB and sCD40L from human platelets: role of HSP27 phosphorylation via p44/p42 MAPK.
Thromb. Res. 2010;126:39-43.

7. Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kozawa O and Moriwaki H. Rho-kinase negatively regulates epidermal growth factor-stimulated colon cancer cell proliferation.
Int. J. Oncol. 2010;36:585-592.

8. Yasuda E, Kumada T, Toyoda H, Kaneoka Y, Maeda A, Okuda S, Yoshimi N and Kozawa O. Evaluation for clinical utility of glypican-3 (GPC3), measured by a commercially available ELISA kit with GPC3 antibody, as a serological and histological marker for hepatocellular carcinoma.
Hepatol. Res. 2010;40:477-485.

9. Natsume H, Tokuda H, Adachi S, Takai S, Matsushima-Nishiwaki R, Kato K, Minamitani C, Niida S, Mizutani J, Kozawa O and Otsuka T. Rho-kinase limits FGF-2-stimulated VEGF release in osteoblasts.
Bone. 2010;46:1068-1074.

10. Adachi S, Yasuda I, Natsume H, Nakashima M, Moriwaki H and Kozawa O. HSP90 inhibitors induce down-regulation of EGF receptor via p38 MAPK-mediated phosphorylation at Ser1046/7 in human pancreatic cancer cells.
Oncol. Rep. 2010;23:1709-1714.

11. Tanabe K, Matsushima-Nishiwaki R, Yamaguchi S, Iida H, Dohi S and Kozawa O. Mechanisms of tumor necrosis factor--induced interleukin-6 synthesis in glioma cells.
J. Neuroinflamm. 2010;7:16.

12.
Natsume H, Tokuda H, Mizutani J, Adachi S, Matsushima-Nishiwaki R, Minamitani C, Kato K, Kozawa O and Otsuka T. Synergistic effect of vasoactive intestinal pepetides on TNF-a-induced IL-6 synthesis in osteoblasts: amplification of p44/p42 MAP kinase activation.
Int. J. Mol. Med. 2010;25:813-817.
13. Kato K, Tokuda H, Natsume H, Adachi S, Matsushima-Nishiwaki R, Minamitani C, Mizutani J, Kozawa O and Otsuka T. Rho-kinase regulates prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts.
Exp. Ther. Med. 2010;1:579-584.
14. Doi T, Adachi S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Natsume H, Kato K, Mizutani J, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O and Ogura S. Antithrombin III reduces collagen-stimulated granule secretion of PDGF-AB and the release of soluble CD40 ligand from human platelets.
Int. J. Mol. Med. 2010;26:387-392.
15. Tanabe K, Matsushima-Nishiwaki R, Dohi S and Kozawa O. Phosphorylation status of heat shock protein 27 regulates the interleukin-1-induced interleukin-6 synthesis in C6 glioma cells.
Neuroscience. 2010;170:1028-1034.
16. Kato K, Tokuda H, Adachi S, Matsushima-Nishiwaki R, Natsume H, Yamakawa K, Gu Y, Otsuka T and Kozawa O. AMP-activated protein kinase positively regulates FGF-2-stimulated VEGF synthesis in osteoblasts.
Biochem. Biophys. Res. Commun. 2010;400:123-127.



Department of Pharmacology, Gifu University Graduate School of Medicine