Department of Pharmacology, Gifu University Graduate School of Medicine




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1. Niwa M, Hara A, Taguchi A, Kozawa O and Mori H. Intriguing expression of HSP20 and its phosphorylation in hippocampal CA1 pyramidal neurons following transient forebrain ischemia.
Neurol Res. 2009;31:721-727.
2. Kuno M, Takai S, Matsushima-Nishiwaki R, Minamitani C, Mizutani J, Otsuka T, Harada A, Adachi S, Kozawa O and Tokuda H. Rho-kinase inhibitors decrease TGF-ƒŔ-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.
Biochem. Pharmacol.
2009;77:196-203.

3. Tokuda H, Hosoi T, Hayasaka K, Okamura K, Yoshimi N and Kozawa O. Overexpression of protein kinase C-ƒÂ plays a crucial role in interleukin-6-producing pheochromocytoma presenting with acute inflammatory syndrome: a case report.
Horm. Metab. Res.
2009;41:333-338.
4. Yamauchi J, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Natsume H, Mizutani J, Otsuka T, Takeda J, Harada A, Kozawa O and Tokuda H. Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts.
Int. J. Mol. Med.
2009;23:267-272.
5. Adachi S, Natsume H, Yamauchi J, Matsushima-Nishiwaki R, Joe AK, Moriwaki H and Kozawa O. p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047.
Cancer Lett
.
2009;277:108-113.

6. Minamitani C, Otsuka T, Takai S, Matsushima-Nishiwaki R, Adachi S, Hanai Y, Mizutani J, Tokuda H and Kozawa O. Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
Int. J. Mol. Med
.
2009;24:77-82.

7. Tanabe K, Nishimura K, Dohi S and Kozawa O. Mechanisms of interleukin-1ƒŔ-induced GDNF release from rat glioma cells.
Brain Res
.
2009;1274:11-20.

8. Natsume H, Mizutani J, Adachi S, Matsushima-Nishiwaki R, Minamitani C, Tokuda H, Kozawa O and Otsuka T. Involvement of Rho-kinase in TGF-ƒŔ-stimulated heat shock protein 27 induction in osteoblasts.
Mol. Med. Rep
.
2009;2:687-691.

9. Natsume H, Adachi S, Takai S, Tokuda H, Matsushima-Nishiwaki R, Minamitani C, Yamauchi J, Kato K, Mizutani J, Kozawa O and Otsuka T. (-)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of phosphatidylinositol 3-kinase/Akt pathway in osteoblasts.
Int. J. Mol. Med
.
2009;24:197-203.

10. Yamaguchi S, Tanabe K, Takai S, Matsushima-Nishiwaki R, Adachi S, Iida H, Kozawa O and Dohi S. Involvement of Rho-kinase in tumor necrosis factor-ƒż-induced interleukin-6 release from C6 glioma cells.
Neurochem. Int
.
2009;55:438-445.

11. Adachi S, Tokuda H, Matsushima-Nishiwaki R, Kato K, Natsume H, Minamitani C, Mizutani J, Otsuka T and Kozawa O. Involvement of Rho-kinase in prostaglandin E1-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells.
Prostag. Oth. Lipid M
.
2009;90:1-6.

12.
Hanai Y, Adachi S, Yasuda I, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Akamatsu S, Sakakibara S, Ogura S, Iwama T, Kozawa O and Tokuda H. Level of collagen-induced p38 MAP kinase activation is a biomarker of platelet hyper-aggregation in patients with diabetes mellitus.
Life Sci
.
2009;85:386-394.
13. Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Niwa M, Tokuda H, Akamatsu S, Doi T, Kato H, Yoshimura S, Ogura S, Iwama T and Kozawa O. ƒżB-crystallin extracellularly suppresses ADP-induced granule secretion from human platelets.
FEBS Lett.
2009;583:2464-2468.
14. Adachi S, Shimizu M, Shirakami Y, Yamauchi J, Natsume H, Matsushima-Nishiwaki R, To S, Weinstein IB, Moriwaki H and Kozawa O. (-)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser 1046/1047 by p38 MAP kinase in colon cancer cells.
Carcinogenesis. 2009;30:1544-1552.
15. Doi T, Adachi S, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O and Ogura S. Antithrombin III suppresses ADP-induced platelet granule secretion: inhibition of HSP27 phosphorylation.
Arch. Biochem. Biophys. 2009;489:62-67.



Department of Pharmacology, Gifu University Graduate School of Medicine