Department of Pharmacology, Gifu University Graduate School of Medicine




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@ [2008]
1. Tokuda H, Takai S, Hanai Y, Harada A, Matsushima-Nishiwaki R, Kato H, Ogura S and Kozawa O. Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts.
J. Bone Miner. Metab. 2008;26:335-341.
2. Tokuda H, Takai S, Hanai Y, Matsushima-Nishiwaki R, Yamauchi J, Harada A, Hosoi T, Ohta T and Kozawa O. (-)-Epigallocatechin gallate inhibits basic fibroblast growth factor-induced interleukin-6 synthesis in osteoblasts.
Horm. Metab. Res. 2008;40:674-678.

3. Takai S, Hanai Y, Matushima-Nishiwaki R, Minamitani C, Otsuka T, Tokuda H and Kozawa O. p70 S6 kinase negatively regulates FGF-2-stimulated IL-6 synthesis in osteoblasts: function at a point downstream from protein kinase C.
J. Endocrinol. 2008;197:131-137.

4. Hayashi K, Takai S, Matsushima-Nishiwaki R, Hanai Y, Kato K, Tokuda H and Kozawa O. (-)-Epigallocatechin gallate reduces transforming growth factor b-stimulated HSP27 induction through the suppression of stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.
Life Sci. 2008;82:1012-1017.
5. Tanabe K, Takai S, Matsushima-Nishiwaki R, Kato K, Dohi S and Kozawa O. a2 Adrenoreceptor agonist regulates protein kinase C-induced heat shock protein 27 phosphorylation in C6 glioma cells.
J. Neurochem.
2008;106:519-528.

6. Kato H, Takai S, Matushima-Nishiwaki R, Adachi S, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Doi T, Ogura S and Kozawa O. HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion.
Arch. Biochem. Biophys.
2008;475:80-86.

7. Matsushima-Nishiwaki R, Takai S, Adachi S, Minamitani C, Yasuda E, Noda T, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A, Kumada T and Kozawa O. Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular-signal-regulated kinase.
J. Biol. Chem.
2008;283:18852-18860.

8. Minamitani C, Otsuka T, Takai S, Matsushima-Nishiwaki R, Adachi S, Hanai Y, Mizutani J, Tokuda H and Kozawa O. Involvement of Rho-kinase in prostaglandin F2-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.
Mol. Cell. Endocrinol.
2008;291:27-32.

9. Adachi S, Nagao T, To S, Joe AK, Shimizu M, Matsushima-Nishiwaki R, Kozawa O, Moriwaki H, Maxfield FR and Weinstein IB. (-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells.
Carcinogenesis.
2008;29:1986-1993.

10. Minamitani C, Takai S, Matsushima-Nishiwaki R, Hanai Y, Otsuka T, Kozawa O and Tokuda H. A case of raloxifene-induced acceleration of platelet aggregation.
Internal Med.
2008;47;1523-1528.

11. Tokuda H, Takai S, Matsushima-Nishiwaki R, Hanai Y, Adachi S, Minamitani C, Mizutani J, Otsuka T and Kozawa O. Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.
Prostaglandins Leukot. Essent. Fatty Acids.
2008;79:41-46.

12.
Takai S, Matsushima-Nishiwaki R, Adachi S, Natsume H, Minamitani C, Mizutani J, Otsuka T, Tokuda H and Kozawa O. (-)-Epigallocatechin gallate reduces platelet-derived growth factor-BB-stimulated interleukin-6 synthesis in osteoblasts: suppression of SAPK/JNK.
Mediators Inflamm.2008;2008:291808.



Department of Pharmacology, Gifu University Graduate School of Medicine