Department of Pharmacology, Gifu University Graduate School of Medicine




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@ [2007]
1. Tokuda H, Takai S, Matsushima-Nishiwaki R, Akamatsu S, Hanai Y, Hosoi T, Harada A, Ohta T and Kozawa O. (-) -Epigallocatechin gallate enhances prostaglandin F2a- induced VEGF  synthesis via up-regulating SAPK/JNK activation in osteoblasts.
J. Cell. Biochem. 2007;100:1146-1153.

2. Takai S, Tokuda H, Hanai Y and Kozawa O. Limitation by p70 S6 kinase of PDGF-BB-induced IL-6 synthesis in osteoblast-like MC3T3-E1 cells.
Metabolism 2007;56:476-483.

3. Takai S, Tokuda H, Hanai Y and Kozawa O. Activation of phosphatidylinositol 3-kinase/Akt limits FGF-2-induced VEGF release in osteoblasts.
Mol. Cell. Endocrinol. 2007;267:46-54.

4. Takai S, Tokuda H, Hanai Y, Harada A, Yasuda E, Matsushima-Nishiwaki R, Kato H, Ogura S, Ohta T and Kozawa O. Negative regulation by p70 S6 kinase of FGF-2-stimulated VEGF release through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.
J. Bone Miner. Res. 2007;22:337-346.
5. Takai S, Nagaki M, Imao M, Kimura K, Kozawa O and Moriwaki H. Intrinsic resistance to TNF-a-induced hepatocyte apoptosis in ICR mice correlates with expression of a short form of c-FLIP.
Lab. Invest. 2007;87:572-581.

6. Noda T, Kumada T, Takai S, Matsushima-Nishiwaki R, Yoshimi N, Yasuda E, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A and Kozawa O. Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma.
Oncol. Rep. 2007;17:1309-1314.

7. Tokuda H, Takai S, Hanai Y, Matsushima-Nishiwaki R, Hosoi T, Harada A, Ohta T and Kozawa O. (-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation.
FEBS Lett. 2007;581:1311-1316.

8. Ochiai S, Sekiguchi S, Hayashi A, Shimadzu M, Ishiko H, Matsushima-Nishiwaki R, Kozawa O, Yasuda M and Duguchi T. Decreased affinity of mosaic-structure recombinant penicillin-binding protein 2 for oral cephalosporins in Neisseria gonorrhoeae.
J. Antimicrob. Chemother. 2007;60:54-60.

9. Takai S, Matsushima-Nishiwaki R, Tokuda H, Yasuda E, Toyoda H, Kaneoka Y, Yamaguchi A, Kumada T and Kozawa O. Protein kinase C d regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma.
Life Sci. 2007;81:585-591.

10. Tokuda H, Hanai Y, Matsushima-Nishiwaki R, Yamauchi J, Doi T, Harada A, Takai S and Kozawa O. Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts.
Biochem. Biophys. Res. Commun. 2007;362:799-804.

11. Yamauchi J, Takai S, Matsushima-Nishiwaki R, Hanai Y, Doi T, Kato H, Ogura S, Kato K, Tokuda H and Kozawa O. (-)-Epigallocatechin gallate inhibits prostaglandin D2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in osteoblasts.
Prostaglandins Leukot. Essent. Fatty Acids. 2007;77:173-179.

12. Tokuda H, Takai S, Hanai Y, Harada A, Matsushima-Nishiwaki R, Akamatsu S, Ohta T and Kozawa O. Platelet-derived growth factor-BB amplifies PGF2a-induced VEGF  synthesis in osteoblasts: function of phosphatidylinositol 3-kinase.
Prostaglandins Leukot. Essent. Fatty Acids. 2007;77:187-193.



Department of Pharmacology, Gifu University Graduate School of Medicine