Department of Pharmacology, Gifu University Graduate School of Medicine


研究業績リスト

 [2005]
1. Hirade K, Tanabe K, Niwa M, Ishisaki A, Nakajima K, Nakamura M, Sugiyama T,
  Katagiri Y, Kato K and Kozawa O: Adenylyl cyclase-cAMP system inhibits
  thrombin-induced HSP27 in vascular smooth muscle cells.
  J. Cell. Biochem. 94:575-584, 2005
2. Kanno Y, Ishisaki A, Yoshida M, Tokuda H, Numata O and Kozawa O: SAPK/JNK
  plays a role in transforming growth factor-β-induced VEGF synthesis in
  osteoblasts.
  Horm. Metab. Res. 37:140-145, 2005
3. Kanno Y, Ishisaki A, Yoshida M, Nakajima K, Tokuda H, Numata O and Kozawa O:
  Adenylyl cyclase-cAMP system inhibits thyroid hormone-stimulated osteocalcin
  synthesis in osteoblasts.
  Mol. Cell. Endocrinol. 229:75-82, 2005
4. Matsuno H, Tokuda H, Ishisaki A, Shu E, Kitajima Y and Kozawa O: P2Y12 receptors
  play a significant role on the development of platelet micro-aggregation in
  patients with diabetes.
  J. Clin. Endocr. Metab. 90:920-927, 2005
5. Kumada M, Niwa M, Hara A, Matsuno H, Mori H, Ueshima S, Matsuo O, Yamamoto T
  and Kozawa O: Tissue type plasminogen activator facilitates NMDA-receptor-mediated
  retinal apoptosis through an independent fiblinolytic cascade.
  Invest. Ophth. Vis. Sci. 46:1504-1507, 2005 
6. Yoshida M, Kanno Y, Ishisaki A, Tokuda H, Hirade K, Nakajima K, Katagiri Y,
  Shimizu K and Kozawa O: Methotrexate suppresses inflammatory agonists-induced
  interleukin-6 synthesis in osteoblasts.
  J. Rheumatology. 32:787-795, 2005
7. Yasuda E, Tokuda H, Ishisaki A, Hirade K, Kanno Y, Hanai Y, Nakamura N, Noda T,
  Katagiri Y and Kozawa O: PPAR-γ ligands up-regulate basic fibroblast growth
  factor-induced VEGF release through amplifying SAPK/JNK activation in
  osteoblasts.
  Biochem. Biophys. Res. Commun. 328:137-143, 2005
8. Nakajima K, Hirade K, Ishisaki A, Matsuno H, Suga H, Kanno Y, Shu E, Kitajima Y,
  Katagiri Y and Kozawa O: Akt regulates thrombin-induced HSP27 phosphorylation
  in aortic smooth muscle cells:function at a point downstream from p38 MAP kinase.
  Life Sci. 77:96-107, 2005
9. Tanabe K, Akamatsu S, Suga H, Takai S, Kato K, Dohi S and Kozawa O: Midazolam
  suppresses thrombin-induced heat shock protein 27 phosphorylation through
  inhibition of p38 mitogen-activated protein kinase in cardiac myocytes.
  J. Cell. Biochem. 96:56-64, 2005
10.Yoshida M, Tokuda H, Ishisaki A, Kanno Y, Harada A, Shimizu K and Kozawa O:
  Tiludronate inhibits prostaglandin F2a-induced vascular endothelial growth factor
  synthesis in osteoblasts.
  Mol. Cell. Endocrinol. 236:59-66, 2005
11.Noda T, Tokuda H, Yoshida M, Yasuda E, Hanai Y and Kozawa O: Possible involvement
  of phosphatidylinositol 3-kinase/Akt pathway in insulin-like growth factor-I-
  induced alkaline phosphatase activity in osteoblasts.
  Horm. Metab. Res. 37:270-274, 2005
12.Suga H, Nakajima K, Shu E, Kanno Y, Hirade K, Ishisaki A, Matsuno H, Tanabe K,
  Akamatsu S, Kato K, Oiso Y and Kozawa O: Possible involvement of
  phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27
  phosphorylation in aortic smooth muscle A10 cells.
  Arch. Biochem. Biophys. 438:137-145, 2005
13.Shu E, Matsuno H, Akamatsu S, Kanno Y, Suga H, Nakajima K, Ishisaki A, Kato K,
  Kitajima Y and Kozawa O: αB-crystallin is phosphorylated during myocardial
  infarction: involvement of platelet-derived growth factor-BB.
  Arch. Biochem. Biophys. 438:111-118, 2005
14.Yasuda E, Kumada T, Takai S, Ishisaki A, Noda T, Matsushima-Nishiwaki R,
  Yoshimi N, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A and Kozawa O: Attenuated
  phosphorylation of heat shock protein 27 correlates with tumor progression in
  patients with hepatocellular carcinoma.
  Biochem. Biophys. Res. Commun. 337:337-342, 2005



Department of Pharmacology, Gifu University Graduate School of Medicine