Department of Pharmacology, Gifu University Graduate School of Medicine


研究業績リスト

 [2002]

1. Hirade K, Kozawa O, Tanabe K, Niwa M, Matsuno H, Oiso Y, Akamatsu S, Ito H,
  Kato K, Katagiri Y, Uematsu T: Thrombin stimulates dissociation and induction of
  HSP27 via p38 MAPK in vascular smooth muscle cells.
  
Am J Physiol Heart Circ Physiol 283 : H941-H948, 2002  

2. Yamamoto T, Kozawa O, Tanabe K, Akamatsu S, Matsuno H, Dohi S. Hirose H,
  Uematsu T: 1,25-Dihydroxyvitamin D3 stimulates vascular endothelial growth
  actor release in aortic smooth muscle cell: role of p38 mitogen-activated protein
  kinase.
  
Arch Biochem Biophys. 398 : 1-6, 2002  

3. Hatakeyama D, Kozawa O, Niwa M, Matsuno H, Ito H, Kato K, Tatematsu N,
  Shibata T, Uematsu T: Upregulation by retinoic acid of transforming growth factor-
  β-stimulated heat shock protein 27 induction in osteoblasts: involvement of
  mitogen-activated protein kinases.
  
Biochim Biophys Acta Mol Cell Res. 1589 : 15-30, 2002  

4. Matsuno H, Kozawa O, Yoshimi N, Akamatsu S, Hara A, Mori H, Okada K,
  Ueshima S, Matsuo O, Uematsu T: Lack of α2-antiplasmin promotes pulmonary
  heart failure via overrelease of VEGF after acute myocardial infarction.
  
Blood. 100 : 2487-2493, 2002  

5. Kozawa O, Otsuka T, Uematsu T: Leukemia inhibitory factor enhances
  bFGF-induced IL-6 synthesis in osteoblasts: involvement of JAK2/STAT3.
  
Cell Signal. 14 : 311-315, 2002  

6. Kozawa O, Hatakeyama D, Tokuda H, Oiso Y, Matsuno H, Uematsu T:
  Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts:
  role of cramide.
  
Cell Signal. 14 : 999-1004, 2002

7. Hotta K, Niwa M, Hirota M, Kanamori Y, Matsuno H, Kozawa O, Otsuka T, Matsui
  N, Uematsu T: Regulation of fluoroquinolone uptake by human neutrophils:
  involvement of mitogen-activated protein kinase.
  
J Antimicrob Chemother. 49 : 953-959, 2002  

8. Niwa M, Kanamori Y, Hotta K, Matsuno H, Kozawa O, Fujimoto S, Uematsu T:
  Priming by grepafloxacin on respiratory burst of human neutrophils: its possible
  mechanism.
  
J Antimicrob Chemother. 50 : 469-478, 2002  

9. Matsuno H, Kozawa O, Okada K, Ueshima S, Matsuno O, Uematsu T: Inhibitors of
  fibrinolytic components play different roles in the formation and removal of
  arterial thrombus in mice.
  
J Cardiovasc Pharmacol. 39 : 278-286, 2002

10. Tanabe K, Kozawa O, Niwa M, Yamamoto T, Matsuno H, Ito H, Kato K, Dohi S,
  Uematsu T: Contrasting effects of midazolam on induction of heat shock protein 27
  by vasopressin and heat in aortic smooth muscle cells.
  
J Cell Biochem. 84 : 39-46, 2002  

11. Kozawa O, Hatakeyama D, Uematsu T: Divergent regulation by p44/42 MAP
  kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated
  osteocalcin synthesis in osteoblasts.
  
J Cell Biochem. 84 : 583-589, 2002

12. Hatakeyama D, Kozawa O, Otsuka T, Shibata T, Uematsu T: Zinc suppresses IL-6
  synthesis by prostaglandin F2α in osteoblasts: inhibition of phospholipase C and
  phospholipase D.
  
J Cell Biochem. 85 : 621-628, 2002

13. Kozawa O, Niwa M, Hatakeyama D, Tokuda H, Oiso Y, Matsuno H, Kato K, and
  Uematsu T: Specific Induction of Heat Shock Protein 27 by Glucocorticoid in
  Osteoblasts.
  
J Cell Biochem. 86 : 357-364, 2002  

14. Wang X, Tokuda H, Hirade K, Kozawa O: Stress-activated protein kinase/c-Jun
  N-terminal kinase (JNK) plays a part in endothelin-1-induced vascular endothelial
  growth factor synthesis in osteoblasts.
  
J Cell Biochem. 87 : 417-423, 2002  

15. Matsuno H, Uematsu T, Niwa M, Kozawa O, Nagashima S, Kohno K, Kato H,
  Kawabata Y, Yoshida Y, Kanamaru M: Pharmacokinetic and pharmacodynamic
  properties of a new thromboxane receptor antagonist (Z-335) after single and
  multiple oral administrations to healthy volunteers.
  
J Clin Pharmacol. 42 : 782-790, 2002  

16. Tokuda H, Kozawa O, Niwa M, Matsuno H, Kato K, Uematsu T: Mechanism of
  prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like
  MC3T3-E1 cells.
  
J Endocrinol. 172 : 271-281, 2002  

17. Kozawa O, Matsuno H, Niwa M, Hatakeyama D, Oiso Y, Kato K, Uematsu T:
   HSP20, low-molecular-weight heat shock-related protein, acts extracellularly as a
   regulator of platelet functions: a novel defense mechanism.
   
Life Sci. 72 : 113-124, 2002  

18. Wang X, Niwa M, Hara A, Matsuno H, Kawase K, Kozawa O, Mori H, Uematsu T:
  Neuronal degradation in mouse retina after a transient ischemia and protective
  effect of hypothermia.
  
Neurol Res. 24 : 730-735, 2002  

19. Tokuda H, Kozawa O, Uematsu T: Interleukin (IL)-17 enhances proataglandin F2α
  -stimulated IL-6 synthesis in osteoblasts.
  
Prostag Leukotr Ess Fatty Acids. 66 : 427-433, 2002  

20. Matsuno H, Kozawa O, Okada K, Ueshima S, Matsuo O, Uematsu T: Plasmin
  generation plays different roles in the formation and removal of arterial and
  venous thrombus in mice.
  
Thromb Haemost. 87 : 98-104, 2002  

21. Takei M, Matsuno H, Okada K, Ueshima S, Matsuo O and Kozawa O: Lack of
  α2-antiplasmin enhances ADP induced platelet micro-aggregation through the
  presence of excess active plasmin in mice.
  
J. Thromb. Thrombolys 14:205-211, 2002


Department of Pharmacology, Gifu University Graduate School of Medicine