研究業績
(1)Wntシグナル伝達系の機能と制御
(2)Apc遺伝子(APC蛋白質)の形態形成における役割 に関連するもの
- Miyashiro I, Senda T, Matsumine A, Baeg G-H, Kuroda T, Shimano T, Miura S,
Noda T, Kobayashi S, Monden M, Toyoshima K, Akiyama T
Subcellular localization of the APC protein : immunoelectron microscopic study of the association of the APC protein with catenin.
Oncogene 11:89-96(1995)
- Matsumine A, Ogai A, Senda T, Okumura N, Satoh K, Baeg G-H, Kawahara T,
Kobayashi S, Okada M, Toyoshima K, Akiyama T
Binding of APC to the human homolog of the Drosophila discs large tumor
suppressor protein.
Science 272 : 1020-1023 (1996)
- Senda T, Miyashiro I, Matsumine A, Baeg G-H, Monden T, Kobayashi S,
Monden M, Toyoshima K, Akiyama T
The tumor suppressor protein APC colocalizes with β-catenin in the colon epithelial cells.
Biochem Biophys Res Commun 223 : 329-334 (1996)
- Matsumine A, Senda T, Baeg G-H, Roy B C, Nakamura Y, Noda M, Toyoshima K,
Akiyama T
MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase.
J Biol Chem 271 : 10341-10346 (1996)
- Senda T, Matsumine A, Akiyama T, Kobayashi S
Association of the MCC gene product with the plasma membrane and membrane organelles.
Med Electron Microsc 30 : 1-7 (1997)
- Senda T, Iino S, Matsushita K, Matsumine A, Kobayashi S, Akiyama T
Localization of the adenomatous polyposis coli tumor suppressor protein in the mouse central nervous system.
Neuroscience 83 : 857-866 (1998)
- Senda T, Matsumine A, Yanai H, Akiyama T
Localization of MCC (mutated in colorectal cancer) in various tissues of
mice and its involvement in cell differentiation.
J Histochem Cytochem 47 : 1149-1158 (1999)
- Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, Higuchi O,
Akiyama T
Asef, a link between the tumor suppressor APC and G-protein signaling.
Science 289 : 1194-1197 (2000)
- Kakinuma N, Nishimura Y, Akiyama T, Senda T
APC is colocalized with β-catenin and hDLG in the Henle’s loop of the
mouse kidney.
Acta Histochem Cytochem 33 : 457-463 (2000)
- Satoh K, Kasai M, Ishidao T, Tago K, Ohwada S, Hasegawa Y, Senda T, Takada S,
Nada S, Nakamura T, Akiyama T
Anteriorization of neural fate by inhibitor of β-catenin and T cell factor
(ICAT), a negative regulator of Wnt signaling.
Proc Natl Acad Sci USA101 : 8017-8021 (2004)
- Shimomura A, Kohu K, Akiyama T, Senda T
Subcellular localization of the tumor suppressor protein APC in developing cultured neurons.
Neurosci Lett 375 : 81-86 (2005)
- Iizuka-Kogo A, Shimomura A, Senda T
Colocalization of APC and DLG at the tips of cellular protrusions in cultured epithelial cells and its dependency on cytoskeletons.
Histochem Cell Biol 123: 67-73 (2005)
- Senda T, Shimomura A, Iizuka-Kogo A
Adenomatous polyposis coli (Apc) tumor suppressor gene as a
multifunctional gene.
Anat Sci Int 80 : 121-131 (2005)
- Takamori N, Shimomura A, Senda T
Microtubule-bundling activity of APC is stimulated by interaction with PSD-95.
Neurosci Lett403: 68-72 (2006)
- Iizuka-Kogo A, Ishidao T, Akiyama T, Senda T
Abnormal development of urogenital organs in Dlgh1-deficient mice.
Development 134 : 1799-1807 (2007)
- Shimomura A, Ohkuma M, Iizuka-Kogo A, Kohu K, Nomura R, Miyachi E,
Akiyama T, Senda T
Requirement of the tumour suppressor APC for the clustering of PSD-95
and AMPA receptors in hippocampal neurons.
Eur J Neurosci 26 : 903-912 (2007)
- Hasegawa Y, Satoh K, Iizuka-Kogo A, Shimomura A, Nomura R, Akiyama T, Senda T
Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesisn.
Biochem Biophys Res Commun 362 : 988-994 (2007)
- Senda T, Iizuka-Kogo A, Onouchi T, Shimomura A
Adenomatous polyposis coli (APC) plays multiple roles in the intestinal
and colorectal epithelia.
Med Mol Morphol 40 : 68-81(2007)
- Hasegawa Y, Iizuka-Kogo A, Akiyama T, Senda T
High expression of Pitx-2 in the ICAT deficient metanephros leads to developmental arrest.
Acta Histochem Cytochem43 : 51-59 (2010)
- Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A,
Aburatani H, Nakamura T, Akiyama T
Identification of a link between Wnt/β-catenin signaling and the cell fusion
pathway.
Nat Commun 2, Article number:548 doi:10.1038/ncomms1551 (2011)
- Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A,
Smits R, Oda N, Fodde R, Itoh M, Senda T
The C-terminal domain of the adenomatous polyposis coli (Apc) protein is
involved in thyroid morphogenesis and function.
Med Mol Morphol 44 : 207-212 (2011)
- Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A,
Smits R, Fodde R, Itoh M, Senda T
Some fine-structural findings on the thyroid gland in Apc1638T/1638T mice
that express a C-terminus lacking truncated Apc.
Med Mol Morphol 45 : 161-167 (2012)
- Shimomura A, Takasaki A, Nomura R, Hayashi N, Senda T
Identification of DNA-dependent protein kinase catalytic subunit as a
novel interaction partner of lymphocyte enhancer factor 1.
Med Mol Morphol 46 : 14-19 (2013)
- Kogo A, Akiyama A, Senda T
Decreased Apoptosis and Persistence of the Common Nephric Duct During the
Development of an Aberrant Vesicoureteral Junction in Dlg1 Gene-Targeted
Mice.
Anat Rec 296 : 1936-1942 (2013)
- Onouchi T, Kobayashi K, Sakai K, Shimomura A, Smits R, Sumi-Ichinose C, Kurosumi M, Takao K, Nomura R, Iizuka-Kogo A, Suzuki H, Kondo K, Akiyama T,Miyakawa T, Fodde R, Senda T
Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia.
Mol Brain 29 ; 7 (1) : 21 (2014)
- Wang T, Onouchi T, Yamada NO, Senda T,
A disturbance of intestinal epithelial cell population and kinetics in APC1638T mice.
Med Mol Morphol 50(2):94-102 (2017)
- Yamada NO, Wenduerma, Matsuda S, Matsuda S, Senda T
Validation and application of a novel APC antibody in western blotting, immunoprecipitation, and immunohistochemistry.
Med Mol Morphol 51(4):227-236 (2018)
- Li C, Onouchi T, Hirayama M, Sakai K, Matsuda S, Yamada NO, Senda T
Morphological and functional abnormalities of hippocampus in APC1638T/1638T mice.
Med Mol Morphol 54:31-40 (2021)
- Wenduerma, Yamada NO, Wang T, Senda T
A further study on a disturbance of intestinal epithelial cell population and kinetics in APC1638T mice.
Med Mol Morphol doi: 10.1007/s00795-016-0152-5 (2021)
- Rannikmae H, Peel S, Barry S, Senda T, de la Roche M
Mutational inactivation of Apc in the intestinal epithelial compromises cellular organization.
J Cell Sci (in press)
(3)アルツハイマー病抵抗遺伝子の検索に関するもの
(4)がん微小環境における細胞間コミュニケーションの解明に関するもの
- Yamada N, Mori T, Murakami M, Noguchi S, Sakai H, Akao Y, Maruo K
Fascin-1 expression in canine cutaneous and oral melanocytic tumours.
Vet Comp Oncol 10 (4): 303-311 (2012)
- Itoh T, Ito Y, Ohtsuki Y, Ando M, Tsukamasa Y,Yamada N, Naoe T, Akao Y
Microvesicles released from hormone-refractory prostate cancer cells facilitate mouse pre-osteoblast differentiation.
J Mol Histol 43 (5): 509-515 (2012)
- Noguchi S, Mori T, Hoshino Y, Yamada N, Nakagawa T, Sasaki N, Akao Y, Maruo K
Comparative study of anti-oncogenic microRNA-145 in canine and human malignant melanoma.
J Vet Med Sci 74 (1): 1-8 (2012)
- Noguchi S, Mori T, Otsuka Y, Yamada N, Yasui Y, Iwasaki J, Kumazaki M, Maruo K, Akao Y
Anti-oncogenic microRNA-203 induces senescence by targeting E2F3 protein in human melanoma cells.
J Biol Chem 287 (15): 11769-11777 (2012)
- Yamada N, Noguchi S, Mori T, Naoe T, Maruo K, Akao Y
Tumor-suppressive microRNA-145 targets catenin delta-1 to regulate Wnt/beta-catenin signaling in human colon cancer cells.
Cancer Lett 335 (2): 332-342 (2013)
- Yamada N, Nakagawa Y, Tsujimura N, Kumazaki M, Noguchi S, Mori T, Hirata I, Maruo K, Akao Y
Role of Intracellular and Extracellular MicroRNA-92a in Colorectal Cancer.
Transl Oncol 6 (4): 482-492 (2013)
- Kumazaki M, Noguchi S, Yasui Y, Iwasaki J, Shinohara H, Yamada N, Akao Y
Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells.
J Nutr Biochem 11: 1849-1858 (2013)
- Noguchi S, Mori T, Hoshino Y, Yamada N, Maruo K, Akao Y
MicroRNAs as tumour suppressors in canine and human melanoma cells and as a prognostic factor in canine melanomas.
Vet Comp Oncol 11 (2): 113-123 (2013)
- Noguchi S, Yamada N, Kumazaki M, Yasui Y, Iwasaki J, Naito S, Akao Y
Socs7, a target gene of microRNA-145, regulates interferon-beta induction through STAT3 nuclear translocation in bladder cancer cells.
Cell Death Dis 4: e482 (2013)
- Noguchi S, Iwasaki J, Kumazaki M, Mori T, Maruo K, Sakai H, Yamada N, Shimada K, Naoe T, Kitade Y, Akao Y
Chemically modified synthetic microRNA-205 inhibits the growth of melanoma cells in vitro and in vivo.
Mol Ther 21 (6): 1204-1211 (2013)
- Noguchi S, Yasui Y, Iwasaki J, Kumazaki M, Yamada N, Naito S, Akao Y
Replacement treatment with microRNA-143 and -145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K/Akt and MAPK signaling pathways.
Cancer Lett 328 (2): 353-361 (2013)
- Tsugita M, Yamada N, Noguchi S, Yamada K, Moritake H, Shimizu K, Akao Y, Ohno T
Ewing sarcoma cells secrete EWS/Fli-1 fusion mRNA via microvesicles.
PLoS One 8: e77416 (2013)
- Yamada N, Noguchi S, Kumazaki M, Shinohara H, Miki K, Naoe T, Akao Y
Epigenetic regulation of microRNA-128a expression contributes to the apoptosis-resistance of human T-cell leukaemia jurkat cells by modulating expression of fas-associated protein with death domain (FADD).
Biochim Biophys Acta – Molecular cell research 1843 (3): 590-602 (2014)
- Yamada N, Tsujimura N, Kumazaki M, Shinohara H, Taniguchi K, Nakagawa Y, Naoe T, Akao Y
Colorectal cancer cell-derived microvesicles containing microRNA-1246 promote angiogenesis by activating Smad 1/5/8 signaling elicited by PML down-regulation in endothelial cells.
Biochim Biophys Acta - Gene regulatory mechanisms 1839 (11): 1256-1272 (2014)
- Akao Y, Khoo F, Kumazaki M, Shinohara H, Miki K, Yamada N
Extracellular Disposal of Tumor-Suppressor miRs-145 and -34a via Microvesicles and 5-FU Resistance of Human Colon Cancer Cells.
Int J Mol Sci 15 (1): 1392-1401 (2014)
- Kumazaki M, Shinohara H, Taniguchi K, Yamada N, Ohta S, Ichihara K, Akao Y
Propolis cinnamic acid derivatives induce apoptosis through both extrinsic and intrinsic apoptosis signaling pathways and modulate of miRNA expression.
Phytomedicine 21 (8): 1070-1077 (2014)
- Noguchi S, Kumazaki M, Yasui Y, Mori T, Yamada N, Akao Y
MicroRNA-203 regulates melanosome transport and tyrosinase expression in melanoma cells by targeting kinesin superfamily protein 5b.
J Invest Dermatol 134 (2): 461-469 (2014)
- Shinohara H, Taniguchi K, Kumazaki M, Yamada N, Ito Y, Otsuki Y, Uno B, Hayakawa F, Minami Y, Naoe T, Akao Y
Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia.
Cancer Lett 360 (1): 28-38 (2015)
- Taniguchi K, Ito Y, Sugito N, Kumazaki M, Shinohara H, Yamada N, Nakagawa Y, Sugiyama T, Futamura M, Otsuki Y, Yoshida K, Uchiyama K, Akao Y
Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms.
Sci Rep 5, article No. 8647 (2015)
- Taniguchi K, Sugito N, Kumazaki M, Shinohara H, Yamada N, Nakagawa Y, Ito Y, Otsuki Y, Uno B, Uchiyama K, Akao Y
MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer.
Cancer Lett 363 (1): 17-27 (2015)
- Taniguchi K, Sugito N, Kumazaki M, Shinohara H, Yamada N, Matsuhashi N, Futamura M, Ito Y, Otsuki Y, Yoshida K, Uchiyama K, Akao Y
Positive feedback of DDX6/c-Myc/PTB1 regulated by miR-124 contributes to maintenance of the Warburg effect in colon cancer cells.
Biochim Biophys Acta – Molecular basis of disease 1852 (9): 1971-1980 (2015)
- Heishima K, Mori T, Sakai H, Sugito N, Murakami M, Yamada N, Akao Y, Maruo K
MicroRNA-214 Promotes Apoptosis in Canine Hemangiosarcoma by Targeting the COP1-p53 Axis.
PLoS One 10: e0137361 (2015)
- Heishima K, Mori T, Ichikawa Y, Sakai H, Kuranaga Y, Nakagawa T, Tanaka Y, Okamura Y, Masuzawa M, Sugito N, Murakami M, Yamada N, Akao Y, Maruo K
MicroRNA-214 and MicroRNA-126 Are Potential Biomarkers for Malignant Endothelial Proliferative Diseases.
Int J Mol Sci 16 (10): 25377-25391 (2015)
- Yamada N, Kuranaga Y, Kumazaki M, Shinohara H, Taniguchi K, Akao Y
Colorectal cancer cell-derived extracellular vesicles induce phenotypic alteration of T cells into tumor-growth supporting cells with transforming growth factor-β1-mediated suppression.
Oncotarget 7 (19):27033-27043 (2016)
- Shinohara H, Kumazaki M, Minami Y, Ito Y, Sugito N, Kuranaga Y, Taniguchi K, Yamada N, Otsuki Y, Naoe T, Akao Y
Perturbation of energy metabolism by fatty-acid derivative AIC-47 and imatinib in BCR-ABL-harboring leukemic cells.
Cancer Lett 371 (1): 1-11 (2016)
- Kuranaga Y, Yamada N, Kashiwaya M, Nakamura M, Cui L, Kumazaki M, Shinohara H, Sugito N, Taniguchi K, Ito Y, Nakayama T, Uno B, Itoh A, Akao Y
Anti-Oncogenic gem-Dihydroperoxides Induce Apoptosis in Cancer Cells by Trapping Reactive Oxygen Species.
Int J Mol Sci 17 (1):71 (2016)
- Taniguchi K, Sakai M, Sugito N, Kumazaki M, Shinohara H, Yamada N, Nakayama T, Ueda H, Nakagawa Y, Ito Y, Futamura M, Uno B, Otsuki Y, Yoshida K, Uchiyama K, Akao Y
PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors.
Oncotarget 7 (14): 18940-18952 (2016)
- Yamada N, Akao Y
Extracellular vesicles in cancer.
Advances in biomembranes and lipid self-assembly 23: 187-204 (2016)
- Yamada NO
Extracellular vesicles in cancer: current status and challenges.
Transl Cancer Res 5 (suppl 3): S561-S563 (2016)
- Tsujimura N, Yamada NO, Kuranaga Y, Kumazaki M, Shinohara H, Taniguchi K, Akao Y
A novel role of Dickkopf-related protein 3 in macropinocytosis in human bladder cancer T24 cells.
Int J Mol Sci 17 (11): 1846, doi:10.3390/ijms17111846 (2016)
- Yamada NO
Extracellular vesicles: emerging mediators of intercellular communication and tumor angiogenesis.
Ann Transl Med, doi: 10.21037/ atm.2017.01.14 (2017)
- Yamada NO, Heishima K, Akao Y, Senda T
Extracellular vesicles containing microRNA-92a-3p facilitate partial endothelial-mesenchymal transition and angiogenesis in endothelial cells.
Int J Mol Sci 20 (18):4406 (2019)
- Yamada NO, Senda T
Circulating microRNA-92a-3p in colorectal cancer: a review.
Med Mol Morphol doi.org/10.1007/s00795-021-00282-w (2021)