生化学講座
 

著書(和文)
野澤義則:細胞ー膜の構造と機能,最新内科学大系,内科総論, 第2巻 科学としての内科学. 井村裕夫, 尾形悦郎,高久史麿,垂井清一郎 編, 東京,中山書店,1996.81-86
 
野澤義則,熊田裕一:血管平滑筋のリン脂質シグナリング, 血管・血小板の生物学. 日高弘義,大熊 稔,蔵本 淳,池田康夫,島田和幸編,東京,金芳堂,1996,123-133
 
岡野幸雄,中島 茂,野澤義則:IP3と DG,ニューロサイエンス講座 第5巻 二次メッセンジャーと産生酵素. 竹縄忠臣,野村靖幸編,東京, 廣川書店,1997.96-104
 
野澤義則:共通の細胞内信号伝達系, Gタンパク質と細胞内メッセンジャー産生. 標準分子医化学,藤田道也 編,東京,医学書院,1997.376-390
 
野澤義則,中島 茂:イノシトールリン脂質代謝産物レセプター,レセプター分子薬理学的アプローチ,日高弘義,谷口隆之,宇井理生編,東京, 講談社サイエンティフィク,1997.107-115
 
中島 茂,野澤義則:細胞表層の分子構造と細胞間コミュニケーション, シリーズ分子生物学3高等動物の分子生物学.村松正實編,東京,朝倉書店,1998.161-167
 
加納宏行,野澤義則:ホスファチジルイノシトールのリン酸化反応,生物薬科学実験講座 3 脂質・リン脂質. 井上圭三,瀧 孝雄,中川靖一編,東京,廣川書店,1998.201-210
 
足立尊仁,野澤義則:リン脂質による情報伝達,肝臓病学 Basic Science.戸田剛太郎,織田正也, 清澤研道,坪内博仁,中沼安二編, 東京,医学書院,1998.322-328
 
野澤義則:情報伝達とリン脂質代謝,はじめに,生物薬科学実験講座3 脂質・リン脂質,井上圭三, 瀧 孝雄,中川靖一編,東京, 廣川書店,1998. 281-285
 
中島 茂,野澤義則:ホスホリパーゼA2,生物薬科学実験講座5 生体膜の構造と機能.石橋貞彦,寺田 弘編,東京,廣川書店,印刷中
 
坂野喜子,野澤義則:ホスホリパーゼC,生物薬科学実験講座5 生体膜の構造と機能.石橋貞彦,寺田 弘編,東京,廣川書店,印刷中
 
金保安則,野澤義則:ホスホリパーゼD,生物薬科学実験講座5 生体膜の構造と機能.石橋貞彦,寺田 弘編,東京,廣川書店,印刷中
 
著書(欧文)
Nozawa Y, Mirbod F,Banno Y,Ibrahim AS, Nakashima S,Kitajima Y, Cole GT, Ghannoum MA:Lysophospholipase-transacylase as a virulence factor in Candida albicans.In:Genes and Genomes in Medically Important Fungi.Tanaka K,Yamaguchi H,Magee PT eds,Foundation for Advancement of International Science,1996.167-173
 
Umeki S,Nozawa Y:Adenylate and guanylate cyclate in Tetrahymena.In:Signaling Mechanisms in Protozoa and Invertebrates.Csaba G,Mu‥ller WEG eds,Springer-Verlag,Berlin,1996.40-60
 
Kitajima Y,Nozawa Y:Lipid and dimorphism of Candida albicans.In:Progress in Molecular and Subcellular Biology,Vol.17,Lipids of Pathogenic Fungi.Prasad R,Ghannoum MA eds,CRC Press,Inc,New York,1996.220-274
 
Higashida H,Hashii M,Yokoyama S,Takeo M,Hoshi N,Noda M,Zhang ZG,Shahidullah M,Minabe Y,Nakashima S,Nozawa Y:Bradykinin B2 receptors and signal transduction analyzed in NG108-15 neuroblastoma x glioma hybrid cells,B2 receptor-transformed NIH/3T3 fibroblasts. In:Progress in Brain Research,Vol.113,The Polymodal Receptor-A Gateway to Pathological Pain. Kumazawa T,Kruger L,Mizumura K eds,Elsevier,Tokyo,1996.215-230
 
Nakashima S,Banno Y,Nozawa Y:Role of signal-transdusing phospholipase A2,C and D in platelet activation.In:Advances in Molecular and Cell Biology Series,Vol.17,The Platelet. Lapetina EG ed,JAI Press Inc,Greenwich,1997.253-274
 
Nakashima S,Banno Y,Nozawa Y:Platelet phospholipase C and D.In:Handbook of Experimental Pharmacology,Vol.126,Platelets and Their Factors,Bruchhausen V,Walter U eds,Springer-Verlag,Heidelberg,1997.246-261
 
Nozawa Y:A putative virulence factor in Candida albicans - Lysophospholipase - transacylase. In:Fungal Cells in Biodefense Mechanism. Suzuki S,Suzuki M eds,Saikon Publishing Co,Tokyo,1997.107-110
 
Ohguchi K,Nakashima S,Nozawa Y:Phospholipase D development during differentiation of HL60 cells. In:Molecular Biology Intelligence Unit,Phospholipase D,Daniel L W ed,R.G.Landes Company,Austin,in press
 
総説(和文)
中島 茂:血小板活性化と膜リン脂質代謝. 日本血栓止血学会誌 7,2-10 (1996)
 
野澤義則:Rabと血小板. 実験医学 14,242-243 (1996)
 
大口健司,野澤義則:ホスホリパーゼD(PLD)活性調節と低分子量GTP結合蛋白質. 膜 21,177-183(1996)
 
野澤義則,岩崎愛彦,中島 茂:信号伝達と細胞の最終分化,ケラチノサイト. 生体の科学 47, 220-225 (1996)
 
中島 茂,坂野喜子,野澤義則:血小板活性化における膜脂質シグナリング. 血液・腫瘍科 33,424-432(1996)
 
野澤義則:コレステロールと生体膜−基礎と臨床−. 現代医療 28,21-24 (1996)
 
坂野喜子,中島 茂,野澤義則:ヒト血小板膜脂質代謝と情報伝達. 細胞 29,10-13(1997)
 
野澤義則:生体膜脂質を介する情報変換システム. 化学工業 48,26-30 (1997)
 
中島 茂,Fariba Mirbod,北島康雄,野澤義則:Differential display によるCandida albicans 遺伝子探索.日本 医真菌学会雑誌 38,291-295(1997)
 
野澤義則:ホスホリパーゼ研究の今昔,細胞内シグナル伝達. 現代化学 34,71-79 (1997)
 
野澤義則:情報変換素子としての生体膜脂質 ー 新しい展開. 膜 22,292-299(1997)
 
中島 茂,野澤義則:Bradykinin B2 receptor. Molecular Medicine 34,55-56(1997)
 
坂野喜子,野澤義則:細胞膜脂質シグナリングの分子機構. 日本生理学雑誌 60,43-58(1998)
 
加納宏行,中島 茂,北島康雄,野澤義則:Candida albicansのPLD遺伝子クローニング. 日本 医真菌学会雑誌 39,79-83(1998)
 
大口健司,野澤義則:好中球機能とホスホリパーゼD. 炎症と免疫 16,37-43(1998)
 
坂野喜子,野澤義則:膜リン脂質代謝. 蛋白質核酸酵素 43,1800-1805(1998)
 
大口健司,野澤義則:シグナル伝達におけるPKCとPLD. 生体の科学 49,248-252(1998)
 
橋井美奈子,中島 茂:Ras遺伝子発現細胞のカルシウム動態. 日本生理学雑誌 印刷中
 
坂野喜子,野澤義則:ホスホリパーゼC(PLC). 現代医療 印刷中
 
原著 (欧文・国内)
Dohjima T,Kato Y,Banno Y,Ohno T,Nozawa Y,Shimizu K:Preferential down-regulation of phospholipase C-β1(PLC-β1) during the early stage of differentiation in MC3T3-E1 osteoblast cells. Biomed Res 18,445-451(1997)
 
Ojio K,Banno Y,Hyayakawa K,Ito Y,Kato N,Watanabe K,Miyata H,Nozawa Y:Role of Rho family GTP-binding proteins in IgE receptor-mediated phospholipase D activation in mast cells. Biomed Res 19,53-63(1998)
 
Hayakawa K,Banno Y,Nakashima S,Ojio K,Ito Y,Miyata H, Nozawa Y:Decreased phospholipase D activities in ceramide-induced apoptosis of RBL-2H3 mast cells. Biomed Res 19,159-170(1998)

原著 (欧文・国外) 
Nakamura Y,Nakashima S,Kumada T,Ojio K,Miyata H,Nozawa Y:Brefeldin A inhibits antigen- or calcium ionophore-stimulated but not PMA-induced phospholipase D activation in rat basophilic leukemia(RBL-2H3) cells.Immunobiology 195,231-242(1996)
 
Banno Y,Ito Y,Ojio K,Kanoh H,Nakashima S,Nozawa Y:Membrane-associated phospholipase D activity in neural cell line PC12.J Lipid Mediators Cell Signaling 14,237-243(1996)
 
Alam S,Nakashima S,Deyashiki Y,Banno Y,Hara A,Nozawa Y:Molecular cloning of a gene encoding acid α-glucosidase from Tetrahymena pyriformis. J Euk Microbiol 43,295-303(1996)
 
Nagata K,Okano Y,Nozawa Y:Protein kinase C isozymes in human megakaryoblastic leukemia cell line,MEG-01:Possible involvement of the isozymes in the differentiation process of MEG-01 cells. Br J Haematol 93,762-771(1996)
 
Mirbod F,Nakashima S,Kitajima Y,Ghannoum MA,Cannon RD,Nozawa Y:Molecular cloning of a gene encoding translation initiation factor(TIF) from Candida albicans.J Med Mycol 34,393-400(1996)
 
Hashii M,Nakashima S,Yokoyama S,Enomoto K,Minabe Y,Nozawa Y,Higashida H:Bradykinin-activated two signal pathways of protein tyrosine phosphorylation and formation of inositol tetrakisphosphates merge at the Ca2+ influx process in ras-transformed NIH3T3 fibroblast cells. Biochem J 319,649-656(1996)
 
Ojio K,Banno Y,Nakashima S,Kato N,Watanabe K,Lyerly DM,Miyata H,Nozawa Y:Effect of Clostridium difficile toxin B on IgE receptor-mediated signal transduction in rat basophilic leukemia cells:Inhibition of phospholipase D activation.Biochem Biophys Res Commun 224,591-596(1996)
 
Yoshimura S,Nakashima S,Ohguchi K,Sakai H,Shinoda J,Sakai N,Nozawa Y:Differential mRNA expression of phospholipase D(PLD)isozymes during cAMP-induced differentiation in C6 glioma cells. Biochem Biophys Res Commun 225,494-499(1996)
 
Zhao Y,Nakashima S,Nozawa Y:Molecular cloning of delta 9 fatty acid desaturase and growth- associated changes in its mRNA expression in Tetrahymena pyriformis,Eur J Prositol 32,539-544(1996)
 
Ohguchi K,Banno Y,Nakashima S,Kato N,Watanabe K,Lyerly DM,Nozawa Y:Effect of Clostridium difficile Toxin A and Toxin B on Phospholipase D activation in human promyelocytic leukemic HL60 cells. Infect Immun 64,4433-4437(1996)
 
Shirado L,Otsuki T,Yamada O,Nanba M,Nakajima H,Nozawa Y,Ueki A,Yawata Y:Down regulation of protein kinase C during growth enhancement induced by interleukin-6 on a human myeloma cell line,KMS-11. Cancer Lett 107,131-136(1996)
 
Mori S,Sugihara Y,Kitagawa A,Kawai K,Nozawa Y,Ogihara Y:The respiration-impairing effect of rubroskyrin,a toxic metabolite of Penicillium islandicum Sopp,on isolated mitochondria. Mycotoxin Res 12,91-98(1996)
 
Ito Y,Nakashima S,Kanoh H,Nozawa Y:Implication of Ca2+-dependent protein tyrosine phosphorylation in carbachol-induced phospholipase D activation in rat pheochromocytoma PC12 cells.J Neurochem 68,419-425(1997)
 
Ohguchi K,Nakashima S,Tan Z,Banno Y,Dohi S,Nozawa Y:Increased activity of small GTP-binding protein-dependent phospholipase D during differentiation in human promyelocytic leukemic HL60 cells.J Biol Chem 272,1990-1996(1997)
 
Nagata K,Okano Y,Nozawa Y:Differential expression of low Mr GTP-binding proteins in human megakaryoblastic leukemia cell line,MEG-01,and their possible involvement in the differentiation process. Thromb Haemost 77,368-375(1997)
 
Hammond SM,Jenco J M,Nakashima S,Cadwallader K,Gu Q,Cook S,Nozawa Y,Prestwich G D,Frohman M A,Morris AJ:Characterization of two alternately spliced forms of phospholipase D1. J Biol Chem 272,3860-3868(1997)
 
Banno Y,Tamiya-Koizumi K,Oshima H,Morikawa A,Yoshida S,Nozawa Y:Nuclear ADP-ribosylation factor(ARF)-and oleate-dependent phospholipase D(PLD) in rat liver cells. J Biol Chem 272,5208-5213(1997)
 
Kovacs P,Csaba G,Nakashima S,Nozawa Y:Phospholipase D activity in the Tetrahymena pyriformis GL. Cell Biochem Funct 15,53-60(1997)
 
Nakashima T,Takenaka K,Fukazawa S,Ando T,Sakai N,Yamada H,Banno Y,Nozawa Y:Purification of a factor from CSF in patient after SAH which induces the cytosolic free calcium elevation in vascular smooth muscle cells. Neurol Res 19,51-56(1997)
 
Yoshimura S,Sakai H,Nakashima S,Nozawa Y,Shinoda J,Sakai N,Yamada H:Differential expression of Rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation. Mol Brain Res 45,90-98(1997)
 
Sakai H,Nakashima S,Yoshimura S,Nishimura Y,Sakai N,Nozawa Y:Identification of differentially expressed mRNAs during rat C6 glial cell differentiation by mRNA fingerprinting using arbitrarily primed PCR(RAP). Neurosci Lett 229,93-96(1997)

Mirbod F,Nakashima S,Kitajima Y,Nozawa Y:Molecular cloning of a Rho family,CDC42Ca gene from Candida albicans and its mRNA expression chnages during morphogenesis. J Med Mycol 35,173-179(1997)
 
Yoshimura Y,Sakai H,Ohguchi K,Nakashima S,Banno Y,Nishimura Y,Sakai N, Nozawa Y:Changes in the activity and mRNA levels of phospholipase D during ceramide-induced apoptosis in rat glial cells. J Neurochem 69,713-720(1997)
 
Ito Y,Nakashima S,Nozawa Y:Hydrogen peroxide-induced phospholipase D activation in rat pheochroma PC12 cells:Possible involvement of Ca2+-dependent protein tyrosine kinase. J Neurochem 69,729-736(1997)
 
Ohguchi K,Kasai T,Nozawa Y:Tyrosine phosphorylation of 100-115 kDa proteins by phosphatidic acid generated via phospholipase D activation in HL60 granulocytes. Biochim Biophys Acta 1346,301-304(1997)
 
Takemura O S,Banno Y, Nozawa Y:Inhibition of N-formylmethionyl-leucyl-phenylalanine-stimulated tyrosine phosphorylation and phospholipase D activation by quercetin in rabbit neutrophils. Biochem Pharmacol,53,1503-1510(1997)
 
Kato Y,Banno Y,Dohjima T,Kato N,Watanabe K,Tatematsu N,Nozawa Y:Involvement of rho family proteins in prostaglandin F2α-induced phospholipase D activation in the osteoblast-like cell line MC3T3-E1. Prostaglandins 54,475-492(1997)
 
Nakamura M,Nakashima S,Katagiri Y,Nozawa Y:Effect of wortmannin and 2-(4-morpholinyl)-8-phenyl4H-1-benzopyran-4-one(LY294002) on N-formyl-methionyl-leucyl-phenylalanine-induced phospholipase D activation in differentiated HL60 cells. Biochem Pharmacol 53,1929-1936(1997)
 
Mori S,Kawai K,Nozawa Y,Ogihara Y:The interaction of rubroskyrin,a modified bis-anthraquinone pigment from Penicillium islandicum Sopp,with respiratory chain of liver mitochondria. Mycotoxin Res 13,35-42(1997)
 
Adachi T,Nakashima S,Saji S,Nakamura T,Nozawa Y:Possible involvement of pertussis toxin-sensitive G protein in hepatocyte growth factor-induced signal transduction in cultured rat hepatocytes:Pertussis toxin treatment inhibits activation of phospholipid signaling,calcium oscillation,and mitogen-activated protein kinase. Hepatology 26,295-300(1997)
 
Zhao Y,Nakashima S,Andoh M,Nozawa Y:Cloning and sequencing of a cDNA encoding glyceraldehyde-3-phosphate dehydeogenase from Tetrahymena thermophila:Growth-associated changes in its mRNA expression. J Euk Microbiol 44,434-437(1997)
 
Liu B, Nakashima S,Adachi T,Ito Y,Takano T,Shimizu T,Nozawa Y:Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing PAF receptor lacking cytoplasmic C-terminal tail. Biochem J 327,239-244(1997)
 
Nakashima S, Matsuda Y, Akao Y, Yoshimura S, Sakai H,Hayakawa K,Andoh M,Nozawa Y:Molecular cloning and chromosome mapping of rat phospholipase D genes(rPLD1a,rPLD1b and rPLD2). Cytogenet Cell Genet 79,109-113(1997)
 
Sakai H,Nakashima S,Nakatani K,Yoshimura S,Nishimura Y,Sakai N,Nozawa Y:Messenger RNA fingerprinting analysis using arbitrarily primed PCR(RAP) of genes expressed during rat C6 glioma cell differentiation. Brain Tumor Pathol 14,119-123(1997)
 
Nakashima S,Ohguchi K,Frohman M A,Nozawa Y:Increased mRNA expression of phospholipase D(PLD) isozymes during granulocytic differentiation of HL60 cells. Biochim Biophys Acta 1389,173-177(1998)
 
Yoshimura S,Banno Y,Nakashima S,Takenaka K,Sakai H,Nishimura Y,Sakai N,Shimizu S,Eguchi Y,Tsujimoto Y, Nozawa Y:Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death:Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation.J Biol Chem 273,6921-6927(1998)
 
Iwasaki-Bessho Y,Banno Y,Yoshimura S,Ito Y,Kitajima Y,Nozawa Y:Decreased phospholipase D(PLD) activity in ceramide-induced apoptosis of human keratinocyte cell line HaCaT. J Invest Dermatol 110,376-382(1998)
 
Banno Y,Asano T, Nozawa Y:Stimulation by G protein βγsubunits of phospholipase Cβisoforms in human platelets. Thromb Haemost 79,1008-1013(1998)
 
Sakai H,Nakashima S,Yoshimura S,Nishimura Y,Sakai N,Nozawa Y:Molecular cloning of a cDNA encoding a serine protease homologous to complement C1s precursor from rat C6 glial cells and its expression during glial differentiation. Gene 209,87-94(1998)
 
Nakamura M,Nakashima S,Katagiri Y,Nozawa Y:Involvement of tyrosine phosphorylation in inhibition of fMLP-induced PLD activation by N-acetyl-L-cysteine in differentiated HL-60 cells.J Leukocyte Biol 63,781-789(1998)
 
Kanoh H,Nakashima S,Zhao Y,Sugiyama Y,Kitajima Y, Nozawa Y:Molecular cloning of a gene encoding phospholipase D from the pathogenic and dimorphic fungus,Candida albicans. Biochim Biophys Acta 1398,359-364(1998)
 
Nagata K,Okano Y,Nozawa Y:Expression of GTP-binding proteins and protein kinase C isozymes in platelet-like particles derived from megakaryoblastic leukemia cells(MEG-O1).Platelets 9,291-296(1998)
 
Okamoto H,Osawa H,Nakashima S,Takahashi T,Kasemura T, Nozawa Y:Studies on blood compatibility of terpolymers composed of methylmethacrylate methoxypolyethyleneglycol methacrylate and dimethylsiloxane methacrylate. J Biomaterials Sci Polymer Edn 9,943-959(1998)
 
Wang S,Nakashima S,Sakai H,Numata O,Fujiu K,Nozawa Y:Molecular cloning and cell cycle-dependent expression of a novel NIMA-related protein kinase(TpNrK) in Tetrahymena cells. Biochem J 334,197-203(1998)
 
Leidich SD,Ibrahim AS,Fu Y,Koul A,Jessup C,Fonzi W,Mirbod F,Nakashima S,Nozawa Y,Ghannoum MA:Cloning and disruption of the Candida albicans phospholipase B gene,caPLB1. J Biol Chem 273,26078-26086(1998)
 
Mizutani T,Nakashima S,Nozawa Y:Changes in the expression of protein kinase C(PKC),phospholipases C(PLC) and D(PLD) isoforms in spleen,brain and kidney of the aged rat:RT-PCR and Western blot analysis. Mechanism Ageing Develop 105,151-172(1998)
 
Banno Y,Kato M,Hara A,Nozawa Y:Evidence for the presence of multiple forms of sphingosine kinase in human platelets. Biochem J 335,301-304(1998)
 
Nomura T,Tazawa M,Ohtsuki M,Sumi-Ichinose C,Hagino Y,Ota A,Nakashima A,Mori K,Sugimoto T,Ueno O,Nozawa Y,Ichinose H,Nagatsu T:Identification of GTP cyclohydrolase I activity in the ciliated protozoa,Tetrahymena. Comp Biochem Physiol,in press
 
Ito Y,Nakashima S,Nozawa Y:Possible involvement of mitogen-activated protein kinase in phospholipase D activation induced by H2O2,but not by carbachol,in rat pheochromocytoma PC12 cells. J Neurochem,in press
 
Sugiyama Y,Nakashima S,Mirbod F,Kanoh H,Kitajima Y,Channoum MA,Nozawa Y:Molecular cloning of a second phospholipase B gene,caPLB2 from Candida albicans. J Med Mycol,in press
 
その他
Nozawa Y,Mirbod F,Banno Y,Ibrahim AS,Nakashima S,Kitajima Y,Cole GT,Ghannoum MA:Lysophospholipase-transacylase as a virulence factor in Candida albicans. Genes and Genomes in
Medically Important Fungi,Proceedings of the First International Synposium on Deep Mycoses,(ed Tanaka K,Magee PT,Yamaguchi H),Foundation for Advancement of International Science,167-173(1996)
 
Nozawa Y,Nakashima S,Ohguchi K,Banno Y:Membrane lipids and signal transduction. BIO JAPAN’96 Symposium Proceeding 325-332(1996)

野澤義則: 分子細胞生物学辞典,分担執筆,1997
 
野澤義則: 生化学辞典,分担執筆,1998