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Sawada M, Nakashima S, Banno Y, Yamakawa H, Takenaka K, Shinoda J, Nishimura Y, Sakai N, Nozawa Y: Influence of Bax or Bcl-2 overexpression on the ceramide-dependnet apoptotic pathway in glioma cells. Oncogene 19: 3508-3520 (2000)

Sawada M, Nakashima S, Banno Y, Yamakawa H, Hayashi K, Takenaka K, Nishimura Y, Sakai N, Nozawa Y: Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apotosis in C6 glioma cells. Cell Death Differ 7: 761-772 (2000)

Hamaya Y, Takeda T, Dohi S, Nakashima S, Nozawa Y: The effect of pentobarbital, isoflurane, and propofol on immediate-early gene expression in the vital organs of the rat. Anesth Analg 90: 1177-1183 (2000)

Yamakawa H, Ito Y, Naganawa T, Banno Y, Nakashima S, Yoshimura S, Sawada M, Nishimura Y, Nozawa Y, Sakai N: Activation of caspase-9 and -3 during H2O2-induced apoptosis of PC12 cells independnent of ceramide formation. Neurol Res 22: 556-564 (2000)

Yamakawa H, Banno Y, Nakashima S, Sawada M, Yamada J, Yoshimura S, Nishimura Y, Nozawa Y, Sakai N: Increased phospholipase D2 activity during hypoxia-induced death of PC12 cells: its possible anti-apoptotic role. NeuroReport 11: 3647-3650 (2000)

Nagaki M, Naiki T, Brenner DA, Osawa Y, Imose M, Hayashi H, Banno Y, Nakashima S, Nozawa Y, Moriwaki H: Tumor necrosis factor ƒ¿ prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not Fas-mediated apoptosis: role of nuclear factor-ƒÈB. Hepatology 32: 1272-1279 (2000)

Watanabe A, Nakashima S, Adachi T, Saji S, Nozawa Y: Changes in the expression of lipid-mediated signal-transducing enzymes in the rat liver after partial hepatectomy. Surg Today 30: 622-630 (2000)

Koike T, Kuzuya M, Asai T, Kanda S, Cheng XW, Watanabe K, Banno Y, Nozawa Y, Iguchi A: Activation of MMP-2 by Clostridium difficile toxin B in bovine smooth muscle cells. Biochem Biophys Res Commun 277: 43-46 (2000)

Zhao Y, Ehara H, Akao Y, Shamoto M, Nakagawa Y, Banno Y, Deguchi T, Ohishi N, Yagi K, Nozawa Y: Increased activity and intranuclear expression of phospholipase D2 in human renal cancer. Biochem Biophys Res Commun 278: 140-143 (2000)

Sawada M, Nakashima S, Kiyono T, Nakagawa M, Yamada J, Yamakawa H, Banno Y, Shinoda J, Nishimura Y, Nozawa Y, Sakai N: p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells. Oncogene 20: 1368-1378 (2001)

Saji S, Okumura N, Eguchi H, Nakashima S, Suzuki A, Toi M, Nozawa Y, Saji S, Hayashi S: MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells. Biochem Biophys Res Commun 281: 259-265 (2001)

Yamakawa H, Banno Y, Nakashima S, Yoshimura S, Sawada M, Nishimura Y, Nozawa Y, Sakai N: Crucial role of calpain in hypoxic PC12 cell death: Caipain, but nnot caspases, mediates degradation of cytoskeletal proteins and protein kinase C-ƒ¿ and -ƒÂ. Neurol Res 23: 522-530 (2001)

Noda S, Yoshimura S, Sawada M, Nakagawa T, Iwama T, Nakashima S, Sakai N: Role of ceramide during cisplatin-induced apoptosis in C6 cells. J NeuroOncol 52: 11-21 (2001)

Osawa Y, Nagaki M, Banno Y, Yamada Y, Imose M, Nozawa Y, Moriwaki H, Nakashima S: Possible involvement of reactive oxygen species in D-galactosamine-induced sensitization against tumor necrosis factor-a-induced hepatocyte apoptosis. J Cell Physiol 187: 374-385 (2001)

Osawa Y, Banno Y, Nagaki M, Brenner DA, Naiki T, Nozawa Y, Nakashima S, Moriwaki H: TNF-ƒ¿-Induced sphingosine 1-phosphate Inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway In human hepatocytes. J Immunol 167: 173-180 (2001)

Osawa Y, Banno Y, Nagaki M, Nozawa Y, Moriwaki H, Nakashima S: Caspase activation during hepatocyte apoptosis induced by tumor necrosis factor-ƒ¿ in galactosamine-sensitized mice. Liver 21: 309-319 (2001)

Osawa Y, Nagaki M, Banno Y, Nozawa Y, Moriwaki H, Nakashima S: Sphingosine kinase regulates hepatoma cell differntiation: roles of hepatocyte nuclear factor and retinoid receptor. Biochem Biophys Res Commun 286: 673-677 (2001)

Banno Y, Takuwa Y, Akao Y, Okamoto H, Osawa Y, Naganawa T, Nakashima S, Suh P-G, Nozawa Y: Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. J Biol Chem 276: 35622-35628 (2001)

Oishi K, Takahashi M, Mukai H, Banno Y, Nakashima S, Kanaho Y, Nozawa Y, Ono Y: PKN regulates phospholipase D1 through direct interaction. J Biol Chem 276: 18096-18101 (2001)

Murate T, Banno Y, T-Koizumi K, Watanabe K, Mori N, Wada A, Igarashi Y, Takagi A, Kojima T, Asano H, Akao Y, Yoshida S, Saito H, Nozawa Y: Cell type-specific localization of sphingosine kinase 1a in human tissues. J Histochem Cytochem 49845-49855 (2001)

Banno Y, Wang S, Ito Y, Izumi T, Nakashima S, Shimizu T, Nozawa Y: Involvement of ERK and p38 MAP kinase in oxidative stress-induced phospholipase D activation in PC12 cells. Neuroreport 12: 2271-2275 (2001)

Wang S, Banno Y, Nakashima S, Nozawa Y: Enzymatic characterization of phospholipase D of protozoan Tetrahymena cells. J Eukaryot Microbiol 48: 194-201 (2001)

Sawada M, Nakashima S, Kiyono T, Yamada J, Hara S, Nakagawa M, Shinoda J, Sakai N: Acid sphigomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells. Exp Cell Res 273: 157-168 (2002)

Okumura N, Saji S, Eguchi H, Nakashima S, Saji S, Hayashi S: Distinct promoter usage of mdm2 gene in human breast cancer. Oncol Rep 9: 557-563 (2002)

Okumura N, Saji S, Eguchi H, Hayashi S, Saji S, Nakashima S: Estradiol stabilizes p53 protein in breast cancer cell Line, MCF-7. Jpn J Cancer Res (2002)

Nakagawa M, Nakashima S, Banno Y, Hara S, Yamada J, Sawada M, Yano H, Yoshimura S, Shinoda J, and Sakai N: Increased expression and secretion of the protein homologous to complement C1s precursor during cyclic AMP-induced differentiation in rat C6 glioma cells. Mol Brain Res 106: 12-21 (2002)

Osawa Y, Nagaki M, Banno Y, Brenner DA, Asano T, Nozawa Y, Moriwaki H, and Nakashima S: TNF-ƒ¿-induced IL-8 production via NF-ƒÈB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Infect Immun 70: 6294-6301 (2002)

Tan Z, Dohi S, Chen J, Banno Y, Nozawa Y: Involvement of the mitogen-activated protein kinase family in tetracaine-induced PC12 cell death. Anesthesiology 96: 1191-201 (2002)

Kodama H, Shimizu K, Banno Y, Nonomura Y, Oshita H, Akaike A: Calpain inhibition by cerebrospinal fluid and effects of calpain on intrathecal nerve tissue. Spine 27: 1077-1081 (2002)

Akao Y, Kusakabe S, Banno Y, Kito M, Nakagawa Y, Tamiya-Koizumi K, Hattori M, Sawada M, Hirabayasi Y, Ohishi N, Nozawa Y: Ceramide accumulation is independent of camptothecin-induced apoptosis in prostate cancer LNCaP cells. Biochem Biophys Res Commun 294: 363-370 (2002)

Chen J, Dohi S, Tan Z, Banno Y, Nozawa Y: The inhibitory effect of local anesthetics on bradykinin-induced phospholipase D activation in rat pheochromocytoma PC12 cells. Anesth Analg 95: 88-97 (2002)

Wang S, Banno Y, Nozawa Y: Two forms of membrane-bound sphingosine kinase in Tetrahymena and activity changes during growth and the cell cycle. J Eukaryot Microbiol 49: 305-311 (2002)

Yamada J, Yoshimura S, Yamakawa H, Sawada M, Nakagawa M, Hara S, Kaku Y, Iwama T, Naganawa T, Banno Y, Nakashima S, Sakai, N: Cell permeable ROS scavengers, tiron and tempol, rescue PC12 cell death by pyrogallol or hypoxia/reoxygenation. Neurosci Res 45: 1-8 (2003)

Osawa Y, Nagaki M, Banno Y, Brenner DA, Nozawa Y, Moriwaki H, Nakashima S: Expression of the NF-ƒÈB target gene X-ray-inducible immediate early response factor-1 short enhances TNF-ƒ¿ induced hepatocyte apoptosis by inhibiting Akt activation. J Immunol 170: 4053-4060 (2003)

Banno Y, Takuwa Y, Yamada M, Takuwa N, Ohguchi K, Hara A, Nozawa Y: Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells. Biochem J. 369: 363-368 (2003)

Sagawa N, Fujita H, Banno Y, Nozawa Y, Katoh H, Kuzumaki N: Gelsolin suppresses tumorigenicity through inhibiting PKC activation in a human lung cancer cell line, PC10. Br J Cancer 88: 606-612 (2003)

Yamada Y, Hamajima N, Kato T, Iwata H, Yamamura Y, Shinoda M, Suyama M, Mitsudomi T, Tajima K, Kusakabe S, Yoshida H, Banno Y, Akao Y, Tanaka M, Nozawa Y: Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer. J Mol Med 81: 126-131 (2003)

Akaike A, Banno Y, Osawa Y, Oshita H, Fushimi K, Kodama H, Shimizu K: Synergistic induction of apoptosis of rheumatoid arthritis synovial cells by H2O2 and N-acetyl-leucyl-leucyl-norleucinal. J Orthop Sci 8: 346-351 (2003)

Yamada J, Yoshimura S, Yamakawa H, Sawada M, Nakagawa M, Hara S, Kaku Y, Iwama T, Naganawa T, Banno Y, Nakashima S, Sakai, N: Cell permeable ROS scavengers, tiron and tempol, rescue PC12 cell death by pyrogallol or hypoxia/reoxygenation. Neurosci Res 45: 1-8 (2003)

Osawa Y, Nagaki M, Banno Y, Brenner DA, Nozawa Y, Moriwaki H, Nakashima S: Expression of the NF-ƒÈB target gene X-ray-inducible immediate early response factor-1 short enhances TNF-ƒ¿ induced hepatocyte apoptosis by inhibiting Akt activation. J Immunol 170: 4053-4060 (2003)

Aoki K, Ogawa T, Ito Y, Nakashima S: Cisplatin activates survival signals in UM-SCC-23 squamous cell carcinoma and these signal pathways are amplified in cisplatin-resistant squamous cell carcinoma. Oncology Rep 11, 375-379 (2004)

Hara S, Nakashima S, Kiyono T, Sawada M, Yoshimura S, Iwama T, Sakai N: Ceramide triggers caspase activation during ƒÁ-radiation-induced apoptosis of human glioma cells lacking functional p53. Oncology Rep 12, 119-123 (2004)

Hara S, Nakashima S, Kiyono T, Sawada M, Yoshimura S, Yamada J, Iwama T, Banno Y, Shinoda J, Sakai N: p53-Independent ceramide formation in human glioma cells during ƒÁ-radiation-induced apoptosis. Cell Death Differ 11, 853-861 (2004)

Sawada M, Nakashima S, Kiyono T, Shinoda J, Naganawa T, Hara S, Iwama T, Sakai N: Molecular mechanisms of TNF-ƒ¿-induced ceramide formation in human glioma cells. Cell Death Differ 11, 997-1008 (2004)

Tsuchiya Y, Nakashima S, Banno Y, Suzuki Y, Morita H: Effect of high-NaCl or high-KCl diet on hepatic Na+- and K+-receptor sensitivity and NKCC1 expression in rats. Am J Physiol 286, R591-596 (2004)

Fushimi K, Nakashima S, Banno Y, Akaike A, Takigawa M, Shimizu K: Implication of prostaglandin E2 in TNF-ƒ¿-induced release of m-calapin from HCS-2/8 chondrocytes. Oeteoarthritis Cartilage 12, 895-903 (2004)